In the lead up to the O2 simulation, students participate in a two-week civics and science module on outbreak response, then take on roles as clinicians, epidemiologists, government officials, military, media, and the general population.
Jorg Greuel/Getty Images On Sunday, the DNA testing company 23andMe revealed a new genetic analysis that it says will tell its customers if they have an elevated risk of developing the most common, and preventable, form of diabetes.
The Life-Threatening Consequences of Overhyping AI On February 11, The New York Times published a story with the headline “AI Shows Promise Assisting Physicians .” While the article focused on a scientific paper showing how an artificial intelligence system could help doctors diagnose certain conditions, it missed a key part of the AI story: Accuracy does not equal impact.
To uncover those “ potentially infectious materials ,” the Global Polio Eradication Initiative hosts a big table that lists the dates and locations of wild poliovirus outbreaks, and the times each country did live-virus vaccinations, so labs around the world can scan the database and see whether their samples might have originated in a polio-prone area.
“They’re supposed to be on a mission to destroy viruses, and instead they act as a shuttle, delivering measles straight to the closest lymph nodes.” Once they’re in the lymph nodes, a sort of bustling immune system transit hub, the virus hops to its intended target—a subset of cells responsible for making antibodies to remember past pathogens.
(The most common prion disorder in humans, Creutzfeldt-Jakob disease, kills about 500 people per year in the United States.) Sometimes the problem proteins are passed down from an unlucky parent; sometimes they develop spontaneously, a fluke mutation; sometimes they are the result of contagion, making their way into the body from a tainted cornea transplant, or a skin graft, or beef infected with bovine spongiform encephalopathy, also known as mad cow disease.
Rather than trying to develop a wildly expensive, highly speculative therapy that will likely only benefit the billionaire-demigod set, Barzilai wants to convince the FDA to put its seal of approval on an antiaging drug for the rest of us: A cheap, generic, demonstrably safe pharmaceutical that has already shown, in a host of preliminary studies, that it may be able to help stave off many of the worst parts of growing old.
But it highlights how much variation there can be in what front-line physicians know about any new disease.“With any emerging infection, one of the problems we face is getting communication out to the physicians who might be seeing these cases,” says Priya Duggal, a genetic epidemiologist and associate professor at the Johns Hopkins Bloomberg School of Public Health, who, since the first outbreak in 2014, has been running a study of AFM victims and their families, with several colleagues.
The FDA's clearance makes reSET one of the first prescription “digital therapeutics”—an emerging class of evidence-based interventions that are predominantly driven by software rather than drugs.WIRED OPINIONABOUTAndy Coravos is is the CEO of Elektra Labs and a member of the Harvard-MIT Center for Regulatory Science.Earlier this year, digital medicine company Akili Interactive announced that its video game for children with ADHD demonstrated a statistically significant improvement in a randomized, controlled clinical trial.
“It’s important to note that, right now, the medical profession is not recommending this for healthy patients,” Green says.And while Veritas’ test covers 200 genetic predispositions for disease compared to 23andMe’s nine, customers might decide that information isn't worth $1,000—Veritas will be competing with companies like 23andMe on the perceived value of all that genetic information until it can accomplish the sub-$200 genome.To get ahead in that regard, Veritas wants to integrate genetic data into the everyday.
But flu changes all the the time, mutating just enough from season to season that it requires a new vaccine formula, and a fresh shot, every year.The annual repetition means that people think about flu vaccines differently: less like a medical and legal necessity, and more like a seasonal product, the health care equivalent of a pumpkin spice latte, that they can take or leave.An optimistic view is that flu vaccine is only a failure compared to other vaccines.
The current Ebola epidemic could be beyond control, he said, and may—for the first time since the deadly virus was first identified in 1976—become persistently entrenched in the population.The 329 confirmed and probable cases of Ebola infection reported so far have made it the largest outbreak in the nation’s history, with no signs yet of slowing down.
The calls have not stopped since.Allison’s breakthrough was the discovery of a sort of secret handshake that cancer uses to evade the immune system, and a means to block that handshake—what the Nobel committee hailed as “a landmark in our fight against cancer,” which has “revolutionized cancer treatment, fundamentally changing the way we view how cancer can be managed.” (Allison’s co-recipient was Tasuku Honjo of Kyoto University.) Advances in cancer typically come in 50-year increments; the science that Allison and Honjo helped advance, cancer immunotherapy, has made a generational leap seemingly overnight.Adapted from The Breakthrough: Immunotherapy and the Race to Cure Cancer by Charles Graeber.
“Finding those individuals is currently very difficult,” says Logan.In this study, dogs were trained to sniff out malaria through the scent of the disease in samples of socks worn by infected children.Medical Detection DogsAn entomologist by training, Logan spent the early years of his career trying to understand why some people are more attractive to mosquitoes than others.
A raft of work also started to emerge on the affects of changing weather patterns, heat waves, and access to clean water on people’s health. For example, health scientists came to grasp that they need anthropologists, sociologists and economists for a full understanding of the impact of climate change.
It wasn't long before healthcare providers starting using them to examine patients with no symptoms or family history of cardiovascular illness.There's no exact numbers on how common preventive ECG screening is in the US, but according to a recent editorial in the Journal of American Medicine, ECG examinations of asymptomatic patients had become regular features of annual physicals by the early aughts—until professional societies ran cost/benefit analyses on the practice and started advising against it.One of those societies was the US Preventive Services Task Force.
When researchers at the Royal Veterinary College realized the puppers had a canine version of the most common fatal genetic disease in children—Duchenne muscular dystrophy—they began breeding the sick spaniels with beagles to start a canine colony in the hopes of one day finding a cure.Today, scientists report they’ve halted the progression of the disease in some of those doggy descendants using the gene editing tool known as Crispr.In a study published Thursday in Science, a team led by Eric Olson at the University of Texas Southwestern Medical Center used Crispr to successfully modify the DNA of four young dogs, reversing the molecular defect responsible for their muscle wasting disease.