Last year, the BCCDC won a $1.4 million grant from the federal health authority, Health Canada, for a pilot program, led by Tyndall, that will study the effects of giving the Downtown Eastside’s most at-risk drug users a regular allotment of hydromorphone pills (the chemical name for Dilaudid) which they can take home and use instead of buying street drugs.
Should I Stop Ordering Packages? (And Other Covid-19 FAQs)
Plus: What it means to “flatten the curve,” and everything else you need to know about the coronavirus.Physicians are already using a somewhat haphazard collection of antiviral and other drugs for people critically ill with Covid-19, because they don’t have any other options. Nothing—no drug, no vaccine—is approved for use specifically against Covid-19 in the United States, so any new possibility is a hopeful one. Convalescent plasma and hyperimmune globulin join the rarified group of therapeutics that scientists are testing, including a trial of the Ebola drug remdesivir and the much-hyped antimalarial/immune suppressants chloroquine and hydroxychloroquine.Using blood products from people who’ve already beaten a disease is a century-old approach, predating vaccines and antibiotics. Inspired by its use against polio, two physicians at a Naval hospital in Massachusetts tried it on people who had pneumonia as a result of influenza in 1918, with enough success to warrant more tests. The quality of actual studies of efficacy has varied over the decades, but health care workers used convalescent plasma against SARS, MERS, and Ebola. And a couple of studies—small and preliminary—have shown convalescent plasma having some promise against SARS-CoV-2 as well.
It was all promising enough that the FDA wanted to make sure current patients could have access to the plasma at the same time that researchers were starting a more rigorous investigation. “This seems like ancient history, but maybe it isn’t. There have been niche uses of it for a while,” says Michael Joyner, a physiologist at the Mayo Clinic who in March spearheaded the creation of an ad hoc coalition of researchers interested in pursuing the therapy. Joyner is facilitating the 40-center trial of the new therapies approved today by the FDA, with researchers at Johns Hopkins leading the science. (Joyner himself received gamma globulin, a variant of the treatment, as a preventative against hepatitis B in the 1980s, when he was a medical student.)
Some hospitals are already administering convalescent plasma to critical Covid-19 patients, a so-called “compassionate use” that in this case is allowed by what the FDA calls an emergency Investigational New Drug authorization. Compassionate use allows health care workers to prescribe drugs that are otherwise unapproved, if a sick person has no other options available.At Houston Methodist Hospital, James Musser, the chair of Pathology and Genome Medicine, is a friend of Arturo Casadevall, the Johns Hopkins University immunologist who proposed using convalescent serum early in the pandemic. Musser pushed to get his hospital involved, putting out a call for donors—people who had confirmed positive tests for the virus and had gone at least 14 days without symptoms. His hospital is already doing compassionate-use transfusions. “So far, as of yesterday, we’ve transfused four patients,” Musser said on Thursday. He expected a fifth to receive plasma today.
And how’d it work? “The truth is, it’s far too early,” Musser says. “We, nationally, need to do controlled trials and understand, first and foremost, is this a safe therapeutic? There’s lots of reasons to think it will be, but you never know.”
That kind of straight therapeutic use of plasma, until now conducted on a patient-by-patient basis, will expand. Part of what the FDA approved was expanded access, so that places with a lot of blood donors could collect that plasma and send it to hospitals around the country—perhaps hundreds—where doctors want to use it on people who are just starting to decline from Covid-19, but before they need a ventilator. The FDA allowed Joyner’s Mayo Clinic to hold a single authorization for all those hospitals’ use. The American Red Cross, arguably the best organization in the country at collecting and moving blood around, will lead the logistics.
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